Blar i forfatter "Eilertsen, Gro Østli"
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Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis
Nguyen, Thao; Hokstad, Ingrid; Fagerland, Morten; Mollnes, Tom Eirik; Hollan, Ivana; Feinberg, Mark W.; Hjeltnes, Gunnbjørg; Eilertsen, Gro Østli; Mikkelsen, Knut; Agewall, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation in response to treatment, and in development of premature CVD in RA, is limited. Therefore, we examined the effects of methotrexate (MTX) and tumor necrosis factor inhibitors ... -
Antirheumatic therapy is not associated with changes in circulating N-terminal pro-brain natriuretic peptide levels in patients with autoimmune arthritis
Nguyen, Thao H.P.; Fagerland, Morten; Deyab, Gia; Hjeltnes, Gunnbjørg; Hollan, Ivana; Feinberg, Mark W.; Eilertsen, Gro Østli; Mikkelsen, Knut; Agewall, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-25)Background: Patients with autoimmune arthritis (AA) are at increased risk for impaired cardiac function and heart failure. This may be partly due to the effect of inflammation in heart function. The impact of antirheumatic drugs on cardiac dysfunction in AA remains controversial. Therefore, we aimed to examine effects of antirheumatic treatment on serum N-terminal pro-brain natriuretic peptide ... -
The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: An observational longitudinal study
Compagno, Michele; Gullstrand, Birgitta; Eilertsen, Gro Østli; Nilsson, Jan Åke; Lood, Christian; Jönsen, Andreas; Truedsson, Lennart; Sturfelt, Gunnar; Bengtsson, Anders A (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-10)Background: Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship ... -
Association of Achieving Lupus Low Disease Activity State Fifty Percent of the Time With Both Reduced Damage Accrual and Mortality in Patients With Systemic Lupus Erythematosus
Sharma, Chanakya; Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-01)<i>Objective</i> - To assess the impact of achieving Lupus Low Disease Activity State ≥50% of the time (LLDAS‐50) on damage accrual and mortality in an inception cohort of patients with systemic lupus erythematosus (SLE).<p><p> <i>Methods</i> - We used data from the Tromsø Lupus Cohort, a longitudinal population‐based study of all patients with SLE in the 2 northernmost counties in Norway. ... -
BAFF expression is increased in Lupus Nephritis and associated with activation of C1 inhibitor, α-1-acid-glycoprotein and endothelial markers.
Eilertsen, Gro Østli; Ghelue, Marijke van; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)B cell activating factor (BAFF) inhibitor therapy has recently been approved for non-renal Systemic Lupus Erythematosus (SLE). While BAFF plays a role in experimental lupus nephritis (LN), its role human LN is not well studied. Case control study in 102 SLE patients, 30 with LN (+LN) and 72 without LN (-LN) and 31 healthy controls. We analysed BAFF mRNA expression in PBMCs (BAFF-RQ) and serum BAFF ... -
Clinical epidemiology of Systemic Lupus Erythematosus with emphasis on nephritis and autoantibody production
Eilertsen, Gro Østli (Doctoral thesis; Doktorgradsavhandling, 2011-09-09)Systemisk Lupus Erythematosus (SLE) er en kronisk sykdom der immunforsvaret produserer antistoffer som kan angripe kroppens egne organer. I 1997 ble klassifikasjonskriteriene for å stille diagnosen endret slik at flere typer autoantistoffer ble inkludert. For å undersøke mulige endringer etter innføring av de nye 1997 klassifikasjonskriteriene for SLE, delte vi inn pasientene i to grupper. En ... -
Clinical phenotype associations with various types of anti-dsDNA antibodies in patients with recent onset of rheumatic symptoms. Results from a multicentre observational study
Compagno, Michele; Rekvig, Ole Petter; Bengtsson, Anders; Sturfeld, Gunnar; Heegaard, Niels H. H.; Jönsen, Andreas; Jacobsen, Rasmus S.; Eilertsen, Gro Østli; Fenton, Christopher Graham; Truedsson, Lennart; Nossent, Johannes C; Jacobsen, Søren (Journal article; Tidsskriftartikkel, 2014) -
Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus
Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)While it is a common practice to monitor complement levels in patients with systemic lupus erythematosus to aid in flare prediction and detection, it is unclear if this strategy is helpful in preventing subsequent organ damage. We studied longitudinal complement levels in 102 SLE patients during a median follow-up of 13.8 years (IQR 7.0, 23.1). Low complement was defined as C3 < 0.84 g/L and/or ... -
The Impact of Cytokines on the Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus
Raymond, Warren David; Eilertsen, Gro Østli; Shanmugakumar, Sharanyaa; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-15)<i>Introduction</i>: Systemic lupus erythematosus (SLE) reduces the health-related quality of life (HRQoL), even during periods of disease quiescence. We investigated whether subclinical inflammation as reflected by cytokine levels is linked with reduced HRQoL. Methods: A cross-sectional study of SLE patients (<i>n</i> = 52, mean age 47.3, 86.5% female) who completed a Short Form Health Survey-36 ... -
Increased levels of BAFF in patients with Systemic Lupus Erythematosus are associated with acute phase reactants, independent of BAFF genetics: a case control study
Eilertsen, Gro Østli; Van Ghelue, Marijke; Nossent, Johannes C (Journal article; Tidsskriftartikkel, 2011)Objectives. To determine whether increased levels of B-cell activating factor (BAFF) in patients with SLE are due to disease activity or genetic variations in the promoter region of the BAFF gene and BAFF gene expression. Methods. The case-control study included 101 SLE patients and 111 healthy controls. Five single nucleotide polymorphisms (SNPs) in the BAFF promoter region were investigated by ... -
The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus : Epidemiology, Disease Presentation, and Patient Management
Eilertsen, Gro Østli; Becker-Merok, Andrea; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)The influence of the 1997 updated classification criteria for systemic lupus erythematosus: epidemiology, disease presentation, and patient management. Eilertsen GØ, Becker-Merok A, Nossent JC. Department of Rheumatology, Medical School, University of Tromsø, 9037 Tromsø, Norway. gro.ostli.eilertsen@unn.no OBJECTIVE: The 1997 update of the American College of Rheumatology classification ... -
Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression
Pedersen, Hege Lynum; Horvei, Kjersti Daae; Thiyagarajan, Dhivya; Norby, Gudrun; Seredkina, Natalya; Moroni, Gabriella; Eilertsen, Gro Østli; Holdaas, Hallvard; Strøm, Erik Heyerdahl; Bakland, Gunnstein; Meroni, Pier Luigi; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human ... -
Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis
Dorraji, Seyed Esmaeil; Hovd, Aud-Malin Karlsson; Kanapathippillai, Premasany; Bakland, Gunnstein; Eilertsen, Gro Østli; Figenschau, Stine; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)Tertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Here we investigated the presence of mesenchymal stem cells (MSCs) in the development of TLS in murine LN, as well as the role of human MSCs as lymphoid tissue organizer (LTo) cells on the activation of CD4+ T cells from three groups of donors ... -
Soluble erythropoietin receptor levels associate with inflammatory mediators but not with disease activity or cumulative organ damage in patients with systemic lupus erythematosus
Jones, Heather; Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-14)The erythropoietin receptor (EpoR) stimulates erythrocyte proliferation after erythropoietin binding. EpoR belongs to the cytokine receptor superfamily and can be found on macrophages and endothelial cells. As there are no data on the role of EpoR systemic autoimmune diseases, we investigated the role of soluble EpoR (sEpoR) in patients with systemic lupus erythematosus (SLE). In a cross-sectional ...